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Spatially specific immune modulation via HACD44 engagement has been widely recognized as a central mechanism directing fibroblast migration, macrophage polarization, and coordinated ECM organization during skin regeneration [17]

doi: 10.1186/s13075-018-1803-9 80

(PubMed) da Costa KA, Niculescu MD, Craciunescu CN, Fischer LM, Zeisel SH

This vital characteristic makes it absolutely essential for controlled research settings that require repeated solution handling, dose-variation studies, and extended observation over a defined period (typically up to 28 days post-reconstitution)

Research indicates both topical and intraperitoneal administration routes produced similar wound healing effects in animal models